Learning-Dependent Dendritic Spine Plasticity Is Reduced in the Aged Mouse Cortex
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چکیده
منابع مشابه
Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex.
Cognitive functions that require the prefrontal cortex are highly sensitive to aging in humans, nonhuman primates, and rodents, although the neurobiological correlates of this vulnerability remain largely unknown. It has been proposed that dendritic spines represent the primary site of structural plasticity in the adult brain, and recent data have supported the hypothesis that aging is associat...
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Dendritic spines are small protrusions off the dendrite that receive excitatory synaptic input. Spines vary in size, likely correlating with the strength of the synapses they form. In the developing brain, spines show highly dynamic behavior thought to facilitate the formation of new synaptic contacts. Recent studies have illuminated the numerous molecules regulating spine development, many of ...
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In this study, involvement ofvoltage-dependent calcium channels in LTP of responses of rat visual cortex slices was analyzed. Field potentials including EPSP1 and EPSP2 from layers II/III were recorded through stimulation of layer IV. Whereas nifedipine, a L-type calcium channel blocker (L-VDCC), did not considerably affect the LTP of responses, but Ni2+, a relatively selective blocker of T-typ...
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1 Laboratorio de Psicobioloǵıa, División de Neurociencias, CIBO, IMSS, Guadalajara, JAL 44340, Mexico 2Departamento de Bioloǵıa Celular y Molecular, CUCBA, Universidad de Guadalajara, Guadalajara, JAL 45110, Mexico 3Department of Neuroscience, Geneva University School of Medicine, 1211 Geneva, Switzerland 4Otto von Guericke University Magdeburg, Institute of Biology, Leipziger Straße 44, Buildi...
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Dendritic spines are the postsynaptic sites of the majority of excitatory synapses in the mammalian central nervous system. The morphology and dynamics of dendritic spines change throughout the lifespan of animals, in response to novel experiences and neuropathologies. New spines form rapidly as animals learn new tasks or experience novel sensory stimulations. This is followed by a selective el...
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ژورنال
عنوان ژورنال: Frontiers in Neural Circuits
سال: 2020
ISSN: 1662-5110
DOI: 10.3389/fncir.2020.581435